From 1944 till after World War II, Zech studied medicine at the University of Marburg in Germany.
Having left the medical field of study, Lore then picked up biology, chemistry, and physics at the University of Bonn and completed her doctoral thesis at the Max Planck Institute in Tübingen.
At the University Hospital, she specifically committed her time to discussions on chromosome analysis at the Department of Medical Genetics, where she taught many research students.
In March 2013, Zech died from chronic lymphocytic leukemia, a disease she had conducted research on for many years.
Due to the department's beliefs against this idea, Zech worked on proving her theory correct in secret.