Lorenzo is a census-designated place in Cheyenne County, Nebraska, United States.<[2] As of the 2010 census, it had a population of 58.

[3] Lorenzo is located on Nebraska Highway 19, 10 miles (16 km) southwest of Sidney, the county seat, and 3.5 miles (5.6 km) north of the Colorado border.

Lorenzo was a depot on the Chicago, Burlington and Quincy Railroad.

[5] A post office was established at Lorenzo in 1916, and remained in operation until it was discontinued in 1933.

This Cheyenne County, Nebraska state location article is a stub.