Between 1796 and 1807 she made eight complete voyages as a slave ship in the triangular trade in enslaved people.

After the end of British participation in the trans-Atlantic enslaving trade, Lottery became a West Indiaman.

[3] 1st enslaving voyage (1796–1797): Captain William Stringer acquired a letter of marque on 23 May 1796.

2nd enslaving voyage (1797–1798): Captain John Whittle acquired a letter of marque on 10 March 1797.

[6] 3rd enslaving voyage (1798–1799): Captain John Whittle sailed from Liverpool on 5 July 1798.

Lottery sailed from Kingston on 13 February 1799 and arrived back at Liverpool on 13 April.

Leyland instructed Whittle to sail in company with armed vessels on his way to Africa, and on the Middle Passage.

The Jamaican Assembly had just increased the customs duties by £10 per head on any captive who, in the judgement of the commissioners, appeared to be over 25.

Whittle was to maintain strict discipline, ensure that his officers remained sober, and to treat the captives humanly to avoid insurrections and to bring them to market healthy.

Leland laid out the usual schedule of emoluments for Whittle, the surgeon, and the other officers, and forbade all trading on own account.

The surgeon, Dr. John Tebay, received £265 5s 7d in head money, payment for privilege slaves, and a gratuity.

(Tebay died and the cost of his funeral and coffin were deducted from the gross revenue of the voyage.)

After the deduction of these amounts, duties, sales commission to Leyland's agents at Jamaica (Messrs. Bogle & Jopp), and some other items, the "neat proceeds" were £35,192 17s 10d.

[11] 5th enslaving voyage (1801–1802): Captain Whittle sailed from Liverpool on 21 May 1801 and gathered slaves at Bonny.

Captain Charles Kneal sailed from Liverpool on 21 May 1802 and acquired slaves at Bonny.

[10] 7th enslaving voyage (1803–1804): War with France had resumed so Captain Kneal acquired a letter of marque on 29 November 1803.

[1] 8th enslaving voyage (1806–1807): Captain Thomas Harney acquired a letter of marque on 15 September 1806.

[17] Lottery, Richards, master was lost on 30 January 1810 in Dundrum Bay while on a voyage from Liverpool to the Bahamas.