She was taken in prize and between 1798 and 1804 she made five complete voyages as a slave ship in the triangular trade in enslaved people.

Her fourth voyage gave rise to an influential, and exaggerated, estimate of the profitability of trading in enslaved people.

[1] 1st voyage transporting enslaved people (1798–1799): Captain William Brown acquired a letter of marque on 3 March 1798.

[4] 2nd voyage transporting enslaved people (1799–1800): Captain Brown sailed from Liverpool on 17 July 1799.

[5] 3rd voyage transporting enslaved people (1801–1802): Captain George Bernard acquired a letter of marque on 1 May 1801.

[6] 4th voyage transporting enslaved people (1802–1803): Captain Caesar Lawson sailed from Liverpool on 21 May 1802.

[11] 6th voyage transporting enslaved people (1804–loss): Captain Harney sailed from Liverpool on 27 July 1804.

[3] Lloyd's List reported in January 1805 that Louisa, of Liverpool, Hanny, master, had been lost on the coast of Africa.

[13] Louisa, Harney, master, had been on her way to Angola when she was totally lost after she struck a hidden rock at "Cove Lopez".

[17] Captain Harney sailed Lottery on her eighth enslaving voyage, leaving Liverpool on 26 September 1806.