She made eight complete voyages as a Liverpool-based slave ship in the triangular trade in enslaved people.

[2] 1st voyage transporting enslaved people (1798–1799): Captain John Livingston acquired a letter of marque on 9 October 1798.

[3] 2nd voyage transporting enslaved people (1799–1800): Captain Livingston sailed from Liverpool on 26 December 1799.

[7] Princess Amelia acquired captives at Bonny and arrived at St Vincent on 20 October.

[6] 4th voyage transporting enslaved people (1802–1803): Captain Thomas Mullion sailed from Liverpool on 2 April 1802.

[8][a] Because the voyage began during the Peace of Amiens, Captain Thomas Mullion did not acquire a letter of marque.

[4] Princess Amelia acquired captives at Angola and arrived at St Croix on 6 October 1802.

This led the government in the Danish West Indies to encourage the importation of captives prior to the ban taking effect.

Records for the period 1796 to 1799 alone show that 24 British enslaving ships, most of them from Liverpool, arrived at St Croix and imported 6,781 captives.

[11] 5th voyage transporting enslaved people (1804–1805): Captain McDonald sailed from Liverpool on 22 June 1804.

[12] 6th voyage transporting enslaved people (1805–1806): Captain James Dickson acquired a letter of marque on 20 June 1805,[1] and sailed from Liverpool on 11 July.

Princess Amelia gathered captives at Bonny and arrived at Dominica on 14 February 1806, after stopping at Barbados on 18 January.

However, by clearing customs before the deadline, Captain Dickson was able to squeeze out one last legal slave-trading voyage even though Princess Amelia did not actually sail until 18 May.

[1] In February 1810 Lloyd's List reported that Princess Amelia, from Liverpool, was lost in "River St Mary's".