She was married three times; first at the age of 18 to James Huggart, then to John Jackson, and then in 1906 to Daniel Moss.

President Theodore Roosevelt accepted the painting into the White House's permanent art collection.

In 1899, Lottie served as the Bay City, Michigan representative at the National Women’s Suffrage Association Convention in Dunkirk, New York.

In 1897, she helped establish the Phillis Wheatley Home in Detroit, a chapter of the national African‐American women’s club that provided lodging, educational and recreational programs, and a forum for discussing political issues.

She argued: "Colored women ought not to be compelled to ride in smoking cars, and that suitable accommodations should be provided for them."