Christine of Mecklenburg-Güstrow (14 August 1663 – 3 August 1749) was a German noblewoman of the House of Mecklenburg and by marriage Countess of Stolberg-Gedern.

Born in Güstrow, she was the sixth of eleven children born from the marriage of Gustav Adolph, Duke of Mecklenburg-Güstrow and Magdalene Sibylle of Holstein-Gottorp.

From her ten older and younger siblings, eight survived to adulthood: Marie (by marriage Duchess of Mecklenburg-Strelitz), Magdalene, Sophie (by marriage Duchess of Württemberg-Oels), Charles, Hereditary Prince of Mecklenburg-Güstrow, Hedwig (by marriage Duchess of Saxe-Merseburg-Zörbig), Louise (by marriage Queen of Denmark and Norway), Elisabeth (by marriage Duchess of Saxe-Merseburg-Spremberg) and Augusta.

In Güstrow on 14 May 1683, Christine married Louis Christian, Count of Stolberg-Gedern (1652–1710) as his second wife.

Between 1684 and 1705 she had 23 children in 19 pregnancies (including 4 sets of twins).