[1] Wolff went to the Massachusetts Institute of Technology, graduating with a degree in biology and public health in 1918.
[1] After graduation, he considered going to Europe to study music; because World War I, he remained in the United States and went to medical school.
[1] Next, he worked at the Beth Israel Hospital in Boston as the chief of the electrocardiographic laboratory, remaining in this position from 1928 until his retirement in 1964.
[1] In 1930, Wolffe described the eponymously named Wolff-Parkinson-White syndrome with John Parkinson and Paul Dudley White.
[2] In 1920, Wolff married Alice Muscanto, a flute player born in Vilnius, Lithuania.