[2] The district is named Louisa–Muscatine because it is on the border of Louisa and Muscatine counties.

[citation needed] The district, occupying sections of both counties, includes the cities of Letts, Grandview, and Fruitland as well as a portion of the city limits of Muscatine.

[3] It also includes Cranston, an unincorporated area,[2] as well as students from various other local communities.

In 2014, Ky Cochran of the Muscatine Journal wrote that the district "continues to face financial difficulties", and that the superintendent asked the board to not increase his own salary while the board was to increase the salaries of other staff.

The athletic facilities at the campus include a baseball and softball complex and an American football and track center.