Loyalhanna Creek is a 50-mile (80 km) long tributary of the Kiskiminetas River in Westmoreland County in the U.S. state of Pennsylvania.

[7] Decades before the 2000s, the lower end of the creek, beginning above Latrobe, was colored red due to acid from local mines.

In subsequent years, with the growth of environmental sensitivity, a remediation pond was installed near Saint Vincent College that removes 90 percent of the iron oxide from the water.

[8] Sam Sherry, of Wilpen, claimed to have encountered a Bigfoot while night fishing along Loyalhanna Creek on May 17, 1987.

Sherry gained notice from Bigfoot enthusiasts and spent much of his life investigating the phenomenon in the area.