Pouille also lost his opening singles match in the first round of the main draw of his next ATP World Tour tournament in Marseille as a wildcard, this time to Julien Benneteau.

At the 2014 Paris Masters, Pouille entered the singles main draw after defeating Steve Johnson and Jarkko Nieminen in the qualifying rounds.

[9] At the Australian Open, the unseeded pair of Pouille and Adrian Mannarino lost in the doubles semifinals to Jamie Murray and Bruno Soares.

Pouille was the beneficiary of a singles main draw wildcard at the 2016 Monte Carlo Masters; he defeated Nicolas Mahut in the first round and the No.

In April, the unseeded Pouille reached his first ATP World Tour singles final at the BRD Năstase Țiriac Trophy in Bucharest after defeating three seeded players – Ivo Karlović, Paolo Lorenzi and Federico Delbonis in the second round, quarterfinals and semifinals respectively; he lost the final to the unseeded Fernando Verdasco (3–6, 2–6).

29, he was eliminated in the second round of the French Open by lucky loser Andrej Martin, after a first-round win over countryman Julien Benneteau.

Pouille, Gael Monfils and Jo-Wilfried Tsonga became the first French trio to reach the singles quarterfinals of the same Grand Slam tournament in the Open Era.

[9] At the Moselle Open, Pouille (the third seed of the tournament) reached the final after defeating countrymen Pierre-Hugues Herbert, Julien Benneteau and second-seeded, David Goffin.

In the final, Pouille defeated top seed Dominic Thiem (7–6(7–5), 6–2), winning his first ATP World Tour singles title.

As a result, Pouille achieved a career-high ATP singles ranking of 16 on 26 September, overtaking Richard Gasquet to become French No.

Pouille then played against Kyle Edmund in the second round, but was forced to retire in the second set due to a right big toe injury.

7) continued his good performance by reaching the singles semifinals at the Dubai Tennis Championships, where he lost to the top seed and the reigning world No.

11, he defeated four lower-ranked players (Ryan Harrison, Paolo Lorenzi, Adrian Mannarino and Pablo Cuevas) before losing his semifinal to the No.

Pouille won his second career ATP World Tour singles title at the Hungarian Open in Budapest; seeded No.

Lucas finished the 2017 season as the only player to win at least one ATP World Tour singles title on each surface – Budapest (clay), Stuttgart (grass) and Vienna (indoor hard courts).

[23] Pouille was called up to play for France in the 2018 Davis Cup World Group first-round tie against the Netherlands, but he withdrew a few hours before the start of his first singles match on 2 February against Thiemo de Bakker because of torticollis and was replaced by Adrian Mannarino.

[24] Pouille won the fifth ATP World Tour singles title of his career at the Open Sud de France; he saved two match points when he was down 1–6, 3–5 against Jo-Wilfried Tsonga in the semifinals before subsequently defeating Richard Gasquet in the final.

Over the next two weeks, Pouille lost in the singles finals of two ATP World Tour tournaments, losing to Karen Khachanov and Roberto Bautista Agut in Marseille and Dubai respectively.

After winning both singles matches (he defeated Andreas Seppi and Fabio Fognini) in the 2018 Davis Cup World Group quarterfinal tie against Italy, he suffered a mini slump and lost his opening singles match in three consecutive clay court tournaments – Monte Carlo, Budapest and Madrid.

In June, Pouille reached his fourth and final ATP World Tour singles semifinal of 2018 in Stuttgart, where he lost to Milos Raonic.

[9] Pouille failed to advance beyond the singles round of 16 in any of the eight tournaments (Wimbledon, Washington D.C., Toronto, Cincinnati, the US Open, Stockholm, Vienna and Paris) that he played in the second half of 2018.

However, he won all three of thesingles matches that he contested in the 2018 Davis Cup World Group quarterfinal and semifinal ties against Italy and Spain respectively, to help France advance to the final.

On 8 November 2018, Pouille announced that he and Emmanuel Planque, his coach since 2012, had decided to end immediately their player-coach collaboration by mutual agreement.

[26] The following day, Mauresmo resigned from her post as the captain of the French Davis Cup team to avoid a conflict of interest.

Pouille began his season in Sydney, where seeded sixth, he lost in the first round to the Russian qualifier Andrey Rublev in straight sets.

Pouille lost his opening singles match in his next five tournaments (Montpellier, Indian Wells, Miami, Monte Carlo, and Barcelona).

To recover his form, the Frenchman played the ATP Challenger Tour tournament in Bordeaux, where he won the singles title after defeating Mikael Ymer in the final.

[54] Playing as a wildcard at the Moselle Open, he was defeated in the second round by top seed and eventual champion Hubert Hurkacz.

[citation needed] Pouille played the last match of his season as a wildcard at the 2021 Rolex Paris Masters then, losing in the first round of the qualifying draw against Lorenzo Musetti.

In May, Pouille won his first Challenger title in five years at the 2024 Upper Austria Open in Mauthausen, defeating Jozef Kovalik in the final.