In the early 1960s, he worked for fellow artist Carlo Cedroni's Studio Barbato, Éditions Lug in France, and Edizioni Europer in Rome.
Throughout the 1960s and 1970s, Bernasconi became one of Lug's major artists, co-creating a number of major characters such as Wampus, Kabur and Phenix and also Ami Barry, L'Autre, Billy Boyd, Bob Lance, Comte de Saint-Germain, Frères Thunderbolt, Gladiateur de Bronze, Jean Girodet, Jeff Sullivan, Kit Kappa, Sibilla, Starlock and Waki.
In the 1980s, Bernasconi's work appeared in Il Giornalino and he contributed erotic comics to Edifumetto in Milan.
In 2000, he returned to Kabur, Phenix and Wampus for Semic Comics, the successor of Editions Lug.
In 2004, he teamed up with other writers and artists to reclaim the rights to his characters under the banner of Hexagon Comics.