Lucio Sanseverino (1565–1623) was an Italian cardinal of the Roman Catholic Church.
Sanseverino was born in Naples in 1565, the son of Giovanni Giacomo Sanseverino, count of Saponara, and Cornelia Pignatelli, marchioness of Cerchiaro.
After work as a referendary of the Apostolic Signatura under Pope Gregory XIII, he was elected archbishop of Rossano on 2 December 1592, and consecrated on 21 December.
[1] In July 1621 he was created cardinal by Pope Gregory XV.
He took part in the conclave of 1623 that elected Pope Urban VIII, and died in Salerno on 25 December the same year.