House remains more focused on Thirteen's bisexuality and finds the situation an opportunity to delve into her personal life.
House and Foreman go to Thirteen's apartment to search for drugs that might have caused Spencer's illness.
Thirteen suspects that the woman's illness is related to her drug use, but she then finds out that the woman has a long medical history and has seen several doctors over the past few years, along with discovering that she only slept with Thirteen to get to House, who had previously rejected her as a patient.
Foreman confronts Thirteen about her current hard-partying lifestyle, warning her that it is sending her life and job into a downward spiral.
Songs featured in this episode include "Cheap and Cheerful" by The Kills, "Could We Survive" by Joseph Arthur, and "Dark Road" by Annie Lennox.