[2] Lopez-Vargas faced Ruben Villa on 10 May 2019, in the main event of the ShoBox: The New Generation, once again fighting for the vacant WBO International featherweight title.
[4] After successfully bouncing back against two journeymen opponents, Israel Rojas on 30 August 2019 and Marco Antonio Monteros on 21 September 2019, Lopez was booked to face the undefeated Cristian Baez.
[8] Following these two upset victories, Lopez was booked to face the undefeated Isaac Lowe in an IBF featherweight title eliminator bout.
[11] Lopez challenged the reigning IBF featherweight champion Josh Warrington on 10 December 2022, at the First Direct Arena in Leeds, England.
[14] Lopez was booked to make his maiden title defense against Michael Conlan on 27 May 2023, at the SSE Arena in Belfast, Northern Ireland.
[16] Lopez was booked to make a voluntary title defense of his IBF championship against Joet Gonzalez on September 15, 2023, at the American Bank Center in Corpus Christi, Texas.
[20] Lopez made the fourth defense of his IBF featherweight title against Angelo Leo at Tingley Coliseum in Albuquerque, New Mexico on August 10, 2024.