In his amateur debut, aged 10, Lowe beat future British super bantamweight champion Marc Leach.
Lowe fought on the undercard of Carl Frampton vs. Scott Quigg, defeating Marco McCullough by eighth-round stoppage to win the vacant Commonwealth featherweight title on 27 February 2016 at Manchester Arena.
[4] Lowe faced Luis Alberto Lopez at York Hall on 3 December 2021, in a final eliminator for the International Boxing Federation featherweight title.
[5][6] Lowe fought for the vacant World Boxing Council Silver featherweight title against Nick Ball on 23 April 2022, on the undercard of Tyson Fury vs. Dillian Whyte at Wembley Stadium.
[7] Lowe lost to Lee McGregor via unanimous decision on 21 December 2024, at Kingdom Arena in Riyadh, Saudi Arabia as part of the undercard for the heavyweight world title rematch between Oleksandr Usyk and Tyson Fury.