[1] In 2018, she became involved in the re-election campaign of Democratic Senator Bill Nelson as the Hispanic press secretary and spokesperson.

Luisana also served as district director for Florida State Senator José Javier Rodríguez and as deputy director of communications for Miami-Dade County Mayor Daniella Levine Cava, where she collaborated with the integration of Hispanic media in communication plans.

Her tasks included designing messages on topics such as the Temporary Protected Status (TPS) for Venezuelans, immigration, and health care.

[2][3] She subsequently worked as a press secretary and spokesperson for the United States Department of Health and Human Services (HHS) led by Secretary Xavier Becerra,[3] where she collaborated to implement campaigns to improve vaccination rates against the coronavirus among Hispanics and to promote the special enrollment period of the Affordable Care Act (ACA) ordered by Biden in response to the crisis generated by the COVID-19 pandemic.

[2][3][4] On 2 September 2021, the White House announced the addition of Luisana to Biden's presidential team as the new director of Hispanic media,[5][3] replacing Audrey López.