Here she took work at the Oper Breslau.. She was engaged during 1850 and 1851 as a stage singer at the Court Theatre in Kassel where she enjoyed great success as the company's lead soprano under the musical direction of Louis Spohr.

Her reputation established, she was now able to broaden her horizons, touring theatres in various principal north German cities giving a succession of well applauded guest performances, notably in Braunschweig and Hamburg.

Positive press reviews and public reactions adumbrated her future as the leading soprano of the Imperial Court Opera.

Her natural gifts, backed by diligent and intense study, matched with a deep sensitivity to the true artistic potential of her various stage roles, made her well suited to portray leading characters, including Norma, Jessonda, Amalie in Un ballo in maschera, Valentine in Les Huguenots, Mathilde in William Tell.

[6] By the time she retired from the stage, Meyer-Dustmann had also built up a parallel career as a Lieder singer, with a particular focus on the songs of Felix Mendelssohn and Schubert.

[2] On 5 January 1870, together with contralto Rosa Girzick, tenor Gustav Walter and baritone Emil Krauss, she gave the first public performance of the Brahms' Liebeslieder Walzer.

Notable pupils included Lola Beeth, Hedwig Hübsch [de], Ida Krzyzanowski-Doxat, and Helene Wiet.