The original building in Baroque style was begun in 1710, and around 100 years later named after Queen Luise of Prussia.

Karl Friedrich Schinkel made suggestions for the addition of a steeple and interior changes in 1821, which were partly carried out from 1823.

[1] King Frederick I of Prussia who had decreed to grant the citizens a church and finance it, said on the occasion: "Friedrich der Erste, König in Preußen, gewährt eine größere und eigene Stätte zur Abhaltung des Gottesdienstes und lässt diese Parochialkirche auf seine Kosten erbauen und für immer abwechselnd dem Kultus beider protestantischen Bekenntnisse geweiht sein."

)[2] The original plan of the church in Baroque style was by Philipp Gerlach, but it was simplified by Martin Heinrich Böhme [de],[3] a pupil of Andreas Schlüter.

[5] King Friedrich Wilhelm III gave permission to name the church after Queen Luise of Prussia who had died in 1810.