As a senior, he went 8-0 with an 0.90 earned run average (ERA) in 54+2⁄3 innings pitched with 87 strikeouts for the baseball team.

[8] Jackson started 2012 with Hickory, and was promoted to the High-A Myrtle Beach Pelicans during the season.

[2] After the season, he was named the Nolan Ryan Minor League Pitcher of the Year, and an MiLB organization All Star.

[19] In 2015 with Texas he was 0-0 with a 10.80 ERA in 11+2⁄3 innings, and his fastball velocity of 96.8 mph was in the top 5% in baseball.

[20] In 2016, Jackson split the season between Texas (8 games), the 15-day disabled list (back stiffness), and the minor leagues (with Double-A Frisco and Triple-A Round Rock; he was 1-1 with three saves and a 3.69 ERA in 46+1⁄3 innings over 36 relief appearances).

[2] On December 8, 2016, the Rangers traded Jackson to the Atlanta Braves in exchange for pitchers Tyrell Jenkins and Brady Feigl.

[21] In 2017 in the majors he was 2-0 with a 4.62 ERA in 50.2 innings over 43 relief appearances, and the hard-hit percentage against him was 41.5%, in the worst 2% in baseball.

[26] Jackson induced a 60.5% ground ball percentage, the third-highest in baseball (minimum 70 innings).

Prior to the 2022 season, the Braves disclosed that magnetic resonance imaging had revealed damage to the ulnar collateral ligament of Jackson's right elbow.

[33] On January 9, 2023, the San Francisco Giants announced that Jackson had been signed to a two-year contract, for a guaranteed $11.5 million, with a club option for a third season.

[36] After rehab stints with the Single-A San Jose Giants and Triple-A Sacramento River Cats, Jackson was activated from the injured list on May 30.

[37][38][39] On July 29, 2024, the Giants traded Jackson and Jorge Soler to the Atlanta Braves in exchange for Tyler Matzek and Sabin Ceballos.

[40][41] At the end of the season, the Braves declined the option on Jackson's contract, making him a free agent.