[10] Lumican is a major keratan sulfate proteoglycan of the cornea but is ubiquitously distributed in most mesenchymal tissues throughout the body.

[11] Lumican is involved in collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.

[6] Corneal transparency is possible due to the exact alignment of collagen fibers by lumican (and keratocan) in the intrafibrillar space.

[15] Along with other extracellular matrix components, lumican expression was increased in equine flexor tendons six weeks after an injury.

In menopausal endometrial tissue, the level of lumican expression decreases and is also low in pathological compared to normal endometrium.