The school serves over 500 students in grades 9 through 12 who live in the St. Louis, Missouri area.

In addition to a wide variety of elective courses, students take theology classes each year.

In the 2022-2023 school year, Lutheran South had 520 students served by over 50 professional staff, including teachers, counselors and administrators.

LHSS has a diverse co-curricular program, including 39 athletic, cheerleading and dance squads; intramural activities; drama presentations; the Messengers, a worship-through-drama group; an mock trial team; academic games team; and a student council.

Lutheran South's music department utilizes the talents of nearly one-third of the student body.