[1] Villa Duchesne sports include field hockey, volleyball, tennis, lacrosse, soccer, golf, basketball, swimming and diving, cross country, and track and field.

In 2011, Villa Duchesne captured the Missouri Class 3A Volleyball Championship led by a core group of seniors who helped the team to a 2nd-place finish in 2009.

While Villa's teams compete under the "Saints" name, it is not uncommon to see the school's mascot, Sophie the Squirrel, at home games and meets.

Reigning MSHSAA Field Hockey champions for the 2017 and 2018 seasons, defeating MICDS both years.

Some traditions are Conge, Saint Start-Up family picnic, and gouter.