Nerinx Hall began with three pioneer women, Mary Rhodes, Ann Havern and Christina Stuart, who founded the Sisters of Loretto in 1812.

In 1924, Nerinx Hall began educating young women in the Lockwood family home in Webster Groves, Missouri, graduating its first class in May 1925.

In 2002, Nerinx Hall realized plans to "go green", with a biology lab renovation that included a new greenhouse for plant experimentation.

[2] Nerinx Hall is grounded in the belief that educated, empowered and caring young women are vital to today's world and the future.

In the four years a girl spends at Nerinx there are three main priorities: a woman must know herself and her world, diversity enriches while trust empowers, and all people are called to action.

Students are strongly encouraged to join clubs, teams, and participate in fine arts to enrich their interests and interact with peers and classmates.