Chaminade was founded by the Society of Mary in 1910, less than one hundred years after the school's namesake, Blessed Father William Joseph Chaminade, had founded the order, and only sixty years after the Marianists had established themselves in the United States.

Originally it was a boarding and day school, with most of its students residing in the open dormitories that were located on the third and fourth floors of the main building; the priests and brothers of the Society of Mary resided in rooms on the north and south ends of each floor.

In 2002, the West Wing was expanded again, adding middle school classrooms, a cafeteria, and a new library.

Ralph A. Siefert has been President of Chaminade from 1987 to 2020 succeeded by Todd Guidry after his passing in August 2021.

It houses a basketball/volleyball court, a commons area, a concessions stand, locker rooms for men, women and faculty, and a swimming pool.

The pool is not only used by Chaminade students but by other swim and dive teams in the area, such as St. Joseph's Academy and De Smet Jesuit.

[8] As of 2017[update], over 150 students participate in the school band[6] which has won numerous regional and national awards, including first place in the 2010, 2011, and 2012 Midwest Festival of Music.

In 2009, the Drama Club was selected to participate in the International Fringe Festival in Edinburgh, Scotland.

One club is the online webstream program called CSPN (modeled after ESPN) in which sporting events and other activities are livestreamed on the web.

[11] Some Spring Break community service trips have been to "Coal Country" (West Virginia), as well as Mexico, Africa, and Haiti.

[citation needed] It also includes a Global Citizens Club, and membership in the St. Louis Mosaic Ambassador School program.

Sports offered include baseball, basketball, bocce, bowling, cross country, football, golf, hockey, lacrosse, racquetball, rugby, soccer, swimming/diving, tennis, track/field, ultimate frisbee, volleyball, water polo, and wrestling.