Lutz began with the construction of a small train depot on the Tampa Northern Railroad.

The community was named for W. P. Lutz, who was credited with bringing the railroad to town.

In 2000, a replica of the depot was rebuilt in the approximate location, which is now at the intersection of Lutz-Lake Fern Road and U.S. Highway 41.

[5] Part of the movie Edward Scissorhands was filmed on Tinsmith Circle in the neighborhood of Carpenter's Run in north Lutz in Pasco County.

To the north, Lutz is bordered by Land o' Lakes and Wesley Chapel in Pasco County.

U.S. Route 41 runs through the center of Lutz, and Florida State Road 597 forms part of the western border.