The Lyle H. Fulton Memorial Bridge carries I-65 across the Cumberland River about 2 miles (3.2 km) north of downtown Nashville.

The segment of I-65 that the bridge is located on is part of a loop of interstate highways that completely encircle downtown Nashville, known locally as the Downtown Loop.

In addition to the Cumberland River, the bridge also crosses the Cumberland River Greenway at its western end and a surface street at its eastern end.

On March 15, 1971 the bridge was opened to traffic, along with the entirety of I-265 to the southwest and a short segment of I-40 west of downtown Nashville.

[7] In an effort to relieve traffic congestion on I-24 east of downtown Nashville, I-65 was rerouted from a concurrency with that route to the western freeway loop around downtown Nashville in May 2000, replacing I-265.