[3] The village was founded under the Tsardom of Russia in 1660 by peasants from Right-bank Ukraine.

[4] The area had fallen under Russian control as a result of the Khmelnytsky Uprising, with the Cossack Hetmanate swearing fealty to the Russian tsar.

[5][6] By 10 May 2022, a major Ukrainian counterattack around Kharkiv city led to Lyptsi becoming contested, according to GlobalSecurity.org, an American defense think tank.

[7] On 13 September 2022, during another Ukrainian counteroffensive in Kharkiv Oblast, the 247th Battalion of Ukraine's 127th Territorial Defense Brigade announced that its forces had recaptured Lyptsi, raising the Ukrainian flag in the village.

[8][6] As of the 2001 Ukrainian census, the settlement had 4,209 inhabitants, whose native languages were 78.00% Ukrainian, 21.40% Russian, 0.24% Belarusian, 0.12% Armenian, 0.05% Moldovan (Romanian) and 0.02% German.