Lysander is a town in Onondaga County, New York, United States.

The town was named after Lysander,[3] a Spartan military leader, by a clerk interested in the classics.

The southern town line is defined by the Erie Canal-Seneca River complex.

The Oswego, Seneca, and Oneida Rivers join at the eastern town line.

New York State Route 370, West Genesee Road, is an east-west highway in the southern part of Lysander.

New York State Route 31 intersects NY-370 in the southeastern part of Lysander.

New York State Route 690 is a major highway leading out of the southern part of Lysander.