Recently it has been determined that antibodies against LAMP-2 account for a fraction of patients who get a serious kidney disease termed focal necrotizing glomerulonephritis.

Some of this is done via acid hydrolases that degrade foreign materials and have specialized autolytic functions.

[8] They are believed to be significantly involved in operations of the lysosomes, including maintaining integrity, pH and catabolism.

LAMP2, along with LAMP1, interact with E-selectin and galectins to mediate the adhesion of some cancer cells to the ECM.

[11] Along with other genes such as LC3B, p62 and CTSB, a strong up regulation of LAMP2 was detected in perinecrotic areas of glioblastomas.

This suggests that the three glycoproteins are involved in tumor development, specifically in the processes of angiogenesis and tissue remodeling.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.