M-154 begins where Green Road merges with South Channel Drive on Harsens Island at the mouth of the St. Clair River.

From there the road travels northward around the east edge of the island for about 2.5 miles (4.0 km) before it cuts a block inland.

The road runs primarily through sparsely populated areas except where it abuts the shore lines where denser housing exists.

[5] No section of M-154 is listed on the National Highway System,[6] a network of roads important to the country's economy, defense, and mobility.

The original routing started in the northeast corner of the island travelling down Channel Drive to Little Avenue, which does not exist in its entirety today.