[5][6] NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains.

In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions.

Hence NCOR1 assists nuclear receptors in the downregulation of gene expression.

[5][7] Loss of function of this protein significantly increases the strength and power of mouse muscles.

[8] It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 2.