The repeat is considered the ancestral exons, and the NBPF family has been linked to primate evolution.

It is a member of the NBPF family of proteins, which have been linked to possible roles in oncogenesis and tumor suppressor genes.

Repetitive structure with high intergenic and intragenic sequence conservation, both in coding and noncoding regions.

The repetitiveness of it, and the other members of the NBPF gene family is thought to have arisen from segmental duplications on chromosome 1.

[9] and BLAST searches[10] Due to there being 21 other members of the NBPF gene family, there are 21 paralogs of NBPF16.