[7][8][9] The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase.

The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B).

Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis.

Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.

This article on a gene on human chromosome 9 is a stub.