[1] The MT-TV gene is located on the p arm of the non-nuclear mitochondrial DNA at position 12 and it spans 69 base pairs.
[3] MT-TV is a small 69 nucleotide RNA (human mitochondrial map position 1602-1670) that transfers the amino acid valine to a growing polypeptide chain at the ribosome site of protein synthesis during translation.
[4] Mutations in MT-TV which impair oxidate phosphorylation result in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS).
MELAS is a rare mitochondrial disorder known to affect many parts of the body, especially the nervous system and the brain.
[6] Other clinical manifestations associated with MT-TV mutations have included recurrent migraine headaches, muscle weakness and poor coordination, hearing loss, learning disabilities, dementia, and more.