Some of the most popular shows on the channel are the Romanian version of Total Request Live, Hitlist Romania and Dance Floor Chart.

Since its launch, the channel also aired several TV shows and cartoons, like The Osbournes, Yo Momma, Pimp My Ride, Punk'd, Boiling Points, Daria, Beavis and Butt-Head, Where My Dogs At?.

Other shows such as local versions of Chill Out Zone, Alternative Nation or Superock used to be aired on MTV România.

Main Romanian hosts for MTV România are Ella Voineag, VJ Oana, Laura Cosoi and DJ Dox.

Among the international artists that attended the show are Sugababes, Scooter, Kevin Lyttle, Kosheen, Laura Pausini, Uniting Nations, Dina Vass, Sylver, Pachanga and others.