After the intersection reconfiguring around EDSA to relieve traffic, Macapagal Boulevard is now often used to access the SM Mall of Asia to the north and Cavite to the south.

Macapagal Boulevard commences at the intersection with Gil Puyat Avenue Extension near the Cultural Center of the Philippines Complex in Pasay as the logical continuation of Magdalena Jalandoni Street.

Near the Seaside Boulevard junction at Central Business Park 2 are the NAIA Expressway ramps that provide access to Ninoy Aquino International Airport and connect it to the Metro Manila Skyway.

It crosses Pacific Avenue near Marina Baytown East village, where most traffic turns left towards the Manila–Cavite Expressway.

Macapagal Boulevard ends at the southern coast of Asiaworld, with the Las Piñas–Parañaque Critical Habitat and Ecotourism Area as the terminating vista.