[4] The expressway links the Skyway to Ninoy Aquino International Airport and Entertainment City.

Traversing the cities of Pasay and Parañaque, the NAIAX runs along Andrews Avenue, Electrical Road, and NAIA Road, connecting the Skyway to Ninoy Aquino Avenue, Macapagal Boulevard, New Seaside Drive and the Manila–Cavite Expressway.

Before its development, the 1999 Metro Manila Urban Transportation Integrated Study recommended the construction of an interchange at Skyway leading to Terminal 3 of Ninoy Aquino International Airport.

Phase 2 of the NAIA Expressway project was approved by the National Economic and Development Authority board during the presidency of Benigno Aquino III on May 30, 2012.

[16] It included a 4.83-kilometer (3.00 mi) extension of the expressway to Macapagal Boulevard in Entertainment City, Parañaque.

[16] The project was funded through a public-private partnership (PPP) scheme, with San Miguel Corporation winning the bidding for its construction, operation and maintenance.

[21] On December 21, 2016, at exactly 6:00 AM (PHT), the Entertainment City-NAIA Road-SLEX-Skyway segment (including the access ramp to Terminal 3) of the airport expressway was opened to all motorists for the Christmas rush.

[22] By the full opening of NAIAX, CAVITEX was ultimately connected to Skyway and the international airport.

[25] San Miguel Corporation proposed an expansion of the expressway to Bonifacio Global City (BGC), Taguig in 2017.