[1] The Mace Brown Museum of Natural History has an informal but extensive partnership with local (and regional) amateur collectors.

There are also a few small video presentations, "touch me" specimens, and several fossil whale skulls from the Charleston area.

Remaining parts of the collection and displays include some skulls and skeletons of Pleistocene land mammals from the southeastern USA (chiefly Florida and South Carolina), Cretaceous mosasaurs from the Western Interior Cretaceous Seaway, fossil mammals and turtles from the White River badlands of South Dakota, an exhibit on trackways, an exhibit on fossil mammoths and mastodons, an exhibit on fossil preservation (taphonomy), another on turtles, and another on crinoids and other echinoderms.

[3]  Exhibits include a fossil plant display, sloths of the southeast, and elephants of South Carolina.

In 2019, a complete mounted cast skeleton of the ancestral whale Dorudon atrox (Eocene, Egypt) was donated to the museum and installed as a permanent exhibit in the atrium of the Addlestone Library.

Research using the collections at the museum emphasizes the marine vertebrate paleontology of the Carolinas, particularly the early evolution of whales and dolphins.