The Macho River is a tributary of the Mégiscane River, flowing in Quebec, Canada, in the territories of: The Macho River flows entirely in forested territory north-east of the La Vérendrye Wildlife Reserve and on the west side of Gouin Reservoir.

The surface of the river is usually frozen from mid-December to mid-April.

This source of the river is located at: The main hydrographic slopes near the Macho River are: From its source, the Macho River flows over 69.6 kilometres (43.2 mi) according to the following segments: Upper Macho River (segment of 46.7 kilometres (29.0 mi)) Lower Macho River (segment of 26.0 kilometres (16.2 mi)) The Macho River discharges at the bottom of a bay on the north shore of Berthelot Lake (elevation: 385 metres (1,263 ft) which empties onto the north shore of the Mégiscane River The latter is a tributary of Parent Lake (Abitibi) .This latter lake empties into the Bell River, a tributary of Matagami Lake.

in turn flows into the Nottaway River, a tributary of the southeast shore of James Bay.

Specifically, the Macho River flows to: The toponym "Macho River" was formalized on December 5, 1968, at the Commission de toponymie du Québec.