Upon his return to the country, he became a professor at the Jagiellonian University, where he served as a rector eight times (1501–1519), and also twice as a deputy chancellor of the Academia.
His Tractatus de duabus Sarmatiis (Treatise on the Two Sarmatias) is considered the first accurate geographical and ethnographical description of Eastern Europe.
This work also repeated after Jan Długosz and popularised abroad the myth of Sarmatism: that Polish nobility (szlachta) are descendants from the ancient Sarmatians.
Contra pestem sevam regimen and Conservatio sanitatis are his two printed medical treaties, about how to combat epidemics and on benefit of sanitation.
Marek Stachowski: Miechowita's knowledge of East European languages (mainly Hungarian, Lithuanian and Tatar), based on his Tractatus de duabus Sarmatiis (1517).