The company provides aircraft for charter, scenic, medical evacuation, and services a wide range of tourist destinations within Botswana and the Southern Africa region; as well as providing supply flights to camps and lodges within the Okavango Delta and Kalahari regions of Botswana.

[1] The Botswana Travel Guide says of the airline that it "maintains a good reputation as an reliable, high-quality air charter company which doesn't have ties to any of the camps.

"[2] Mack Air was founded at Maun Airport, Botswana in 1994 by Lara and Stuart Mackay with a single Cessna 206 Stationair.

[8] On 6 January 2010 the company's Cessna 208 crashed and was "extensively damaged" upon takeoff from Piajio Airstrip, Chief's Island, Okavango Delta, Botswana when its engine failed.

[9][10] The following is a list of destinations Mack Air flies to as part of its scheduled services, as of February 2022[update]:[11]