[1] Born in Florence, she was educated with her siblings to the humanistic cultures by figures such as Angelo Poliziano.
[3] This marriage brought closer connections for her family and the Vatican, helping her brother Giovanni get appointed as a cardinal.
[3] She used her influence with her father, her brother Piero, and the pope to help friends and poorer people get aid and positions within the church and governments.
[6] She continued in her role of patron, negotiating with Pope Leo and her nephew, Lorenzo to get clients protection, funds, and release from prison and exile.
[7] She died in Rome, and was buried in St. Peter's Basilica by order of her cousin, Pope Clement VII.