Madison Central has a variety of nicknames amongst the student body and overall, The Commonwealth of Kentucky, having their school nicknames being Mad Cent, Mad Central, MadiCentral, "The cousin up North (usually for students attending Madison Southern)" and Central.

Madison Central also has the mistaken alias of "Madison Southern", usually at sporting events where the school is judged, like in Cheerleading or Marching Band.

In 1989, Richmond's city high school (Madison) was dissolved and its students were moved to Central.

[citation needed] In 2003, the school underwent a major renovation project, which included a new cafeteria.

In 2005–2006, an auditorium was built on the school campus, as well as remodeling the hallway section that leads to it and the health building gymnasium, and new sets of classrooms and a lecture hall under the auditorium.