Based on style and location, dating by art critics Hans van Marle, Anna Bovero, and Zera places the work in the late phase of Crivelli's career—around 1490.

[1] It might have originated from its commissioner's private chapel in the Chiesa di San Francesco ad Alto [it] in Ancona.

[1] Characteristic of late Crivelli works, the use of perspective is clear in the background of the scene, with the triple niche and the loggia whose parapet Mary looks out over.

At the sides, two saints of the Franciscan orders emerge into the scene: Francis of Assisi at left with his stigmata and Bernardino of Siena at right carrying the Christogram.

As in other decorative works by Crivelli, Madonna and Child with Saints is marked by its ample use of gold and the intense expressivity of its figures.