Madre de Dios Island (Spanish: Isla Madre de Dios, Spanish pronunciation: [ˈmaðɾe ðe ðjos]) is an uninhabited island in the Magallanes Region, Chile.

Madre de Dios Island is composed partly of limestone and has several natural caves.

In another cave, named Cueva del Pacifico, rock art was discovered in 2006.

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