Mai Kadra (also spelled May Kadra; Tigrinya: ማይ ካድራ) is a town in Tigray Region, Ethiopia near the Sudanese border.

Mai Kadra was the site of the deadliest massacre during the Tigray War.

Mai Kadra is a market town on the Gonder–Humera road, in the Kafta Humera district of the Mi'irabawi (Western) Zone of the Tigray Region.

Approximately 30 kilometers south of Humera, its population was estimated as 4,000 to 4,500.

Prior to the Tigray War, migrant workers, mainly from the Amhara Region but also from a few other areas, would travel to Mai Kadra for seasonal work on large sesame and millet farms.