It broadcasts major sporting and entertainment events such as boxing, professional wrestling, mixed martial arts and concerts.

In previous years, Main Event has also broadcast large concerts for artists such as Christina Aguilera and Beyoncé Knowles.

In November 2008, the channel broadcast a live concert at Etihad Stadium in Melbourne from Dutch violinist, conductor and composer, André Rieu.

During the Australian Football League's 2007–2011 broadcast rights period, Friday Night Football matches as well as selected games played on Saturday afternoon, Saturday night and Sunday afternoon were shown on Main Event to Fox Sports (Australia) subscribers in New South Wales, Queensland and the Australian Capital Territory.

The AFL arrangement ceased as of season 2012, as free-to-air rights holder the Seven Network were permitted to screen these games to northern states on its digital terrestrial multichannel, 7mate.