The Maine-Anjou is a French breed of domestic cattle, raised mainly in the Pays de la Loire region in north-western France.

It was created in the nineteenth century in the historic province of Maine by cross-breeding the local Mancelle dairy cattle with Durham stock from Britain, and was at first called the Durham-Mancelle.

The Maine-Anjou may display the genetic myostatin deficiency which produces "double muscling", but has not been selectively bred for this attribute.

[2]: 236 The Maine-Anjou is reported from eight countries in the world, with an estimated total population of about 60000, of which approximately two thirds are in France.

Maine-Anjou beef from Rouge des Prés cattle raised in the départements of the Deux-Sèvres, the Ille-et-Vilaine, the Loire-Atlantique, the Maine-et-Loire, the Mayenne, the Orne, the Sarthe and the Vendée received Appellation d'Origine Protégée status in 2010.