SR 208 begins at the intersection of Yates Street and Mile Stretch Road at Biddeford Pool.

From there, it continues, signed as northbound but traveling in a southwesterly direction along the outer peninsula that separates the Biddeford Pool from the Atlantic Ocean.

At the intersection of Mile Stretch Road and Bridge Road, SR 208 turns northward meeting SR 9 (Pool Street) near the Biddeford water tower.

State Routes 208 and 9 continue as a concurrent road north into downtown Biddeford.

Speed limits range from 35–50 miles per hour (56–80 km/h) approaching downtown Biddeford.